Hepatocyte Growth Factor Accelerates The Wound Repair Of Cultured
Gastric Mucosal Cells
In this paper the authors investigated
wound repair in gastric mucosal cells treated with hepatocyte growth
factor and the protein kinase inhibitor Genistein.
Hepatocyte Growth Factor Accelerates The Wound Repair Of Cultured
Gastric Mucosal Cells.
Sumio Watanabe, Miyoko Hirose, Xian-En Wang, Kohei Maehiro, Toshio
Murai, Osamu Kobayashi, Akihito Nagahara and Nobuhiro Sato.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Vol.199, No. 3, 1994
SUMMARY:
Effects of hepatocyte growth factor (HGF) on gastric wound repair
were assessed.
Artificial wounds of uniform size were made by mechanical cell
denudation in confluent rabbit gastric mucosal cell sheets. The changes
in wound size were analyzed quantitatively.
The wound repair process contained an initial migration stage and a
later proliferation stage.
The wound was completely repaired in 36 h in controls; this repair
was accelerated by HGF with the induction of cell migration followed by
proliferation and was retarded by tyrosine protein kinase inhibitor
genistein.
HGF might play some roles in gastric ulcer healing.
|