BARRY'S BOOKS


New book in Dutch

Eet vet word slank

Eet vet word slank gepubliceerd januari 2013

In dit boek lees je o.a.: * heel veel informatie ter bevordering van je gezondheid; * hoe je door de juiste vetten te eten en te drinken kan afvallen; * hoe de overheid en de voedingsindustrie ons, uit financieel belang, verkeerd voorlichten; * dat je van bewerkte vetten ziek kan worden.


Trick and Treat:
How 'healthy eating' is making us ill
Trick and Treat cover

"A great book that shatters so many of the nutritional fantasies and fads of the last twenty years. Read it and prolong your life."
Clarissa Dickson Wright


Natural Health & Weight Loss cover

"NH&WL may be the best non-technical book on diet ever written"
Joel Kauffman, PhD, Professor Emeritus, University of the Sciences, Philadelphia, PA




 
 
   
 
   
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Soy Online Service
 
   
 
   
 

Phytoestrogens & your Pets

Dangers of Soy Based Food Products

by Allan F. Manning © (March 1997) ;

BASIS OF THE FOLLOWING REPORTS

Sexual development in Wild Life, as in humans is controlled by the Endocrine system, a group of organs, tissues and cells that secrete hormones. The hormones interact with other cells initiating chemical biological reactions with far-reaching consequences. Male hormones are called androgens and female hormones are called Estrogens. Some chemicals disrupt the endocrine system and one of these chemicals is found in Soy bean products. Therefore the only safe dose of this hormone disrupter of the endocrine system is zero. In birds these chemicals in any form or amount decrease fertility and progressively get worse within just a few generations. Evidence suggests these sex characteristics once imprinted may be irreversible. 

Some of the information concerning the facts have been known and reported from way back in 1981. The following extracts of just a few of these reports and findings are as follows: 

An extract from "DISEASES OF CAGE BIRDS" (T.F.H. 1987)

 
  • As in all animals iodine is required for thyroxin synthesis. a deficiency in the diet can result in decreased secretion of the hormone. Other factors can also stimulate the appearance of thyroid dysfunction. Many plants provide goitrogenic principles that inhibit thyroxin synthesis even when iodine is adequately supplied. One of these plants is known to be soybean. 

1987 REPORT ON CAPTIVE BREEDING CHEETAHS

 
  • Many North American Zoos cannot maintain their Cheetah populations because deaths have outnumbered births. In 1985 the Zoos reported 29 deaths and only 18 births of which 7 died before reaching adulthood. Analysis of their diet by high performance liquid chromatography and gas-liquid chromatography spectrometry, revealed large amounts of two phytoestrogens identified as daidzein and genistein. These compounds were found to be derived from a Soybean product that was a component of the Cheetahs diet. Therefore Zoos may be one of the major factors in the decline of fertility and in the etiology of liver disease in this species. Their survival in captivity could depend upon a simple change of diet by excluding exogenous estrogen.

THE POTENTIAL ADVERSE EFFECTS OF SOYBEAN PHYTOESTROGENS IN INFANT FEEDING REPORTED FROM CAMBRIDGE UNIVERSITY IN 1991 AND PUBLISHED IN 1994

 
  • It is well established that soybean products contain the phytoestrogen daidzein and genistein. The levels of these compounds in several Soy-based infant formulas have been measured, The quantities recommended by manufacturers for infants provide an intake of approximately three to five times as much diadzein and genistein that amounts which disrupt the menstrual cycle when fed to pre menopausal women. Exposure to the phytoestrogen during Soy formula feeding is a cause for considerable concern given the greater susceptibility of neonates to oestrogens and the likely duration of exposure through infancy. In other forms of life such as animals and birds the situation is much the same but enhances a much quicker effect as a result.

WARNING BY THE MINISTRY OF HEALTH IN NEW ZEALAND

 
  • It is unfortunate that concerns about Soy formulas have received a negative response from companies producing these products. Dr. Martin Edwards of the Ministry of Health stated he does not wish to unduly damage the industries concerned, but which is the greater tragedy, a loss of confidence in Soy products or a potential health risk to babies, animals and birds. According to Dr. Mark Messina soy formula manufacturers know their products contain phytoestrogens and millions of dollars have been spent on the anticancer properties of this substance, which obviously boosts its sales. But they have not bothered to study the effects of phytostrogens on infants, animals and birds etc.

LETTER TO RICHARD JAMES FROM A VETERINARY CLINIC IN WHANGAREI (BRUCE PICKFORD)

 
  • I have recently been on holiday in Canada and the USA, During a stay in Alaska I visited a Raptor rehabilitation centre in Sitka where I learned that they too used Soybean based granules as feeds for their chicks. They too have had some problems with mortality, early maturation of birds and suspicious deaths. The problem is increasing and information is urgently required concerning Soybean products.

"PARROT SOCIETY NEW ZEALAND" ARTICLE, BY VALERIE JAMES (NOVEMBER 1996)

 
  • In 1992 she was keeping and raising some of the native birds which she had been doing for some years on her own food formulas. However she started to use a commercially made food and her hobby suddenly became a nightmare when the chicks began to sicken and die. The food was promoted as scientifically developed and as such was not suspected initially. Autopsies of the dead birds indicated an immune system breakdown with the result of multiple organ failure and a lethal multiplication of the birds own benign bacteria. Survivors often had poor muscle control and matured prematurely, Some were also aggressive or displayed inappropriate sexual behaviour. a chemist carefully tested the food and found it contained a structure which was almost that of coumarin, a substance upon which most modern rodent baits are based. Coumarin was once allowed in small amounts in human food as an aromatic flavour enhancer but has long since been banned when it was shown to be cumulatively toxic when fed to animals. The three ingredients of the bird food were found to be Soy protein isolate (as in Soy infant formulas), Soy all and corn flour. There was no trace of this coumarin. However, it was discovered that there were three other plant structures similar to coumarin, all of which can occur in Soy.

    They are:

    1) The fungal toxin zearalenone - - caused by poor storage or poor growing conditions.

    2) Coumestrol, this being present in Soy sprouts and sometimes in the beans.

    3) Insoflavones which are always associated with say protein.

    This occurs in very few other foods for human consumption although it does occur in beer causing the feminization of men who are heavy beer drinkers. Because of the similarity of their chemical structures zearalenone coumestrol and the isoflavones are phytoetrogens (that is estrogen derived from plants causing many of the symptoms noted in the birds). Further research was done and it was discovered that soy beans contain other toxins most of which are only partially reduced by modern processing and have shown in commercial products to cause ill health in animals. So the Soy content of the food especially the Soy isoflavones which are not significantly reduced by processing causes many problems for our animals and especially birds.

    Research up to this date by bird keepers that have withdrawn all Soy based products from their birds diet have shown the disappearance of the problem. However birds and their offspring's previously exposed to Soy had continuing problems into the third and fourth generations.  

CONCLUSION

 

Many problems have been highlighted and recognised as being related to feeding soy based products to our birds. The above examples are only a few extracts of many related reports from many different sources. Although they are all very disturbing the Soy problems relating to the retarding effect on the reproduction/fertility systems of birds is causing the most concern as it appears to be irreversible. It seems bizarre that so many bird products currently in use are Soybean based even though many of the effects have been known and reported for some time now. Wild life preservation programmes have also employed Soybean products and supplements for adult animals and birds as well as infant feeds for cats and parrots etc. It is established clearly that all soy foods contain toxic substances causing chronic poisoning and endocrine system disruption at very low levels, This effects all forms of life that we feed it to including our own infants.

However, for our birds it is critical that something is done now as their are so many feeds on the market that rely on a Soy base. Our birds both for us private keepers and Zoos etc., are already becoming scarce without the addition of this very basic feeding problem we are now faced with. 

MANUFACTURERS MUST TAKE NOTE THAT ALTHOUGH IT MAY BE A VERY COSTLY EXERCISE FOR THEM, AN ALTERNATIVE FEED BASE AND SUPPLEMENTS HAVE GOT TO BE FOUND URGENTLY.

 

Further Reading

Effects of phyto-oestrogens on veal calf prostate histology
Groot MJ

RIKIL - Institute of Food Safety, PO Box 230, NL-6700 AE, Wageningen, The Netherlands

In veal calf production plant-based proteins are frequently included in milk replacer fed to the animals. Since soy products, which are mostly used, are known for their high levels of phyto-oestrogens, the effects of these feeds on the veal calf prostate were examined. Goal was to determine whether these compounds could interfere with histological screening for oestrogenic growth promoters. In a feeding experiment, four groups of veal calves fed plant-based protein-supplemented milk replacer (PBM), containing 5% soy concentrate, 5% soy isolate, 5% wheat gluten and 2% potato protein, for 4 weeks were compared to animals fed dairy-based control feed (DBM); animals treated with estradiol benzoate, diethylstilbestrol and ethinylestradiol served as positive controls. Daidzein and genistein levels measured in feed and urine showed high levels of genistein and daidzein in the soy isolate and soy concentrate supplemented feeds. Genistein and daidzein were also found in the urine of the animals that were fed these feeds. Haematoxylin-eosin-stained prostate sections of PBM-fed animals showed slight hyperplasia and some dilated tubules as compared to the DBM-fed group, but no metaplasia, which is used for screening for oestrogenic hormones. The positive controls showed extensive squamous metaplasia. Immunohistochemical staining for cytokeratin 5 (using RCK 103 monoclonal antibody) in basal cells showed a normal staining pattern of basal cells in the DBM-fed calves and extensive basal cell proliferation and squamous metaplasia in the oestrogen-treated positive control animals. PBM-fed calves showed no increase of basal cell staining but showed elongations of the basal cells in most animals, sometimes resulting in circular figures. It is concluded that the feeds examined in this study did not interfere with histological screening for oestrogens in male veal calves.

Full Abstract here

A reader of "Wise Traditions", the renowned magazine of the Weston A. Price Foundation, recounts her experience of the effects of soy on a feline population. her report is typical of the effects of isoflavones (estrogenic soy toxins). Download the published letter here.

Effect of dietary soy on serum thyroid hormone concentrations in healthy adult cats.
White HL, Freeman LM, Mahony O, Graham PA, Hao Q, Court MH.

Department of Clinical Sciences, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.

OBJECTIVE: To compare effects of short-term administration of a soy diet with those of a soy-free diet on serum thyroid hormone concentrations in healthy adult cats. ANIMALS: 18 healthy adult cats. PROCEDURE: Cats were randomly assigned to receive either a soy or soy-free diet for 3 months each in a crossover design. Assays included CBC, serum biochemical profile, thyroid hormone analysis, and measurement of urinary isoflavone concentrations. RESULTS: Genistein, a major soy isoflavone, was identified in the urine of 10 of 18 cats prior to dietary intervention. Compared with the soy-free diet, cats that received the soy diet had significantly higher total thyroxine (T4) and free T4 (fT4) concentrations, but unchanged total triiodothyronine (T3) concentrations. The T3/fT4 ratio was also significantly lower in cats that received the soy diet. Although the magnitudes of the increases were small (8% for T4 and 14% for fT4), these changes resulted in an increased proportion of cats (from 1/18 to 4/18) that had fT4 values greater than the upper limit of the laboratory reference range. There was no significant effect of diet on any other measured parameter. CONCLUSIONS AND CLINICAL RELEVANCE: Short-term administration of dietary soy has a measurable although modest effect on thyroid hormone homeostasis in cats. Increase in T4 concentration relative to T3 concentration may result from inhibition of 5'-iodothyronine deiodinase or enhanced T3 clearance. Soy is a common dietary component that increases serum T4 concentration in cats.

 

Effect of daidzein on egg-laying performance in Shaoxing duck breeders during different stages of the egg production cycle
Zhao RQ, Zhou YC, Ni YD, Lu LZ, Tao ZR, Chen WH, Chen J.
Key Laboratory of Animal Physiology and Biochemistry, Nanjing Agricultural University, Nanjing, PR China. yzwj@public1.ptt.js.cn

The effect of a phyto-oestrogen, daidzein, on the laying performance of Shaoxing female ducks was examined in three experiments performed at different stages of the egg production cycle. Egg-laying rate, egg weight, egg composition, feed conversion ratio, hatchability characteristics of eggs and body weight, ovary and oviduct weight, as well as changes in serum concentrations of T3, T4 and E2 were recorded as response criteria.

Full Abstract here

 

Effect of dietary soy on serum thyroid hormone concentrations in healthy adult cats.
White HL, Freeman LM, Mahony O, Graham PA, Hao Q, Court MH. Am J Vet Res. 2004 May;65(5):586-91

Short-term administration of dietary soy has a measurable although modest effect on thyroid hormone homeostasis in cats. Increase in T4 concentration relative to T3 concentration may result from inhibition of 5'-iodothyronine deiodinase or enhanced T3 clearance. Soy is a common dietary component that increases serum T4 concentration in cats.

Full Abstract Here

 

Dietary genistein inactivates rat thyroid peroxidase in vivo without an apparent hypothyroid effect.
Chang HC, Doerge DR. Toxicol Appl Pharmacol. 2000 Nov 1;168(3):244-52.

...substantial amounts of TPO activity are lost concomitant to soy isoflavone consumption by normal rats, the remaining enzymatic activity is sufficient to maintain thyroid homeostasis in the absence of additional perturbations.

Full Abstract Here

 

If the thyroid function of rats can be compared to that of humans, then the reduction of thyroid function (thyroid peroxidase) by the soy estrogen of up to 80% could be highly dangerous. These researchers suggest that the thyroid of rats can function even though 80% of its capacity is inhibited if there is no other perturbing factor. In other research this same FDA laboratory  (link to "Anti-thyroid Isoflavones From Soybean") has stated that any substance that inhibits TPO is by definition a potential carcinogen in thyroid tissue (Abstract Here).

 

Goat Testimony from Chet Day Newsletter.

You know how it goes, Goats can eat anything. Well, I about lost my herd before I figured out what was killing them. I was told by a "natural" show goat person, that she and a university did the research, and the best goat feed was a mixture of grains which included corn, barley, oats, sun flowers and soy beans.

Like I said, I about lost my whole herd before I figured out that it was the soy beans that were causing birth defects and death among the herd. Babies were born which couldn't stand (lack of calcium). If they can't stand they couldn't nurse and soon starved to death. Mothers becoming skin and bones and wasting away.

If all that wasn't bad enough, even once I stopped the soy, it took two years to repair the damage done to the adult's health. If an herbivore like goats can't consume soy ... I don't suppose it is all that hot for an omnivore like 'man' to eat soy beans.

Foods Containing Soy by 1988 had killed over 10% of the world's zoo-kept cheetahs

 

Dietary genistein inactivates rat thyroid peroxidase in vivo without an apparent hypothyroid effect.
Chang HC, Doerge DR. Toxicol Appl Pharmacol. 2000 Nov 1;168(3):244-52.

...substantial amounts of TPO activity are lost concomitant to soy isoflavone consumption by normal rats, the remaining enzymatic activity is sufficient to maintain thyroid homeostasis in the absence of additional perturbations.I

Full Abstract Here

 

f the thyroid function of rats can be compared to that of humans, then the reduction of thyroid function (thyroid peroxidase) by the soy estrogen of up to 80% could be highly dangerous. These researchers suggest that the thyroid of rats can function even though 80% of its capacity is inhibited if there is no other perturbing factor. In other research this same FDA laboratory  (link to "Anti-thyroid Isoflavones From Soybean") has stated that any substance that inhibits TPO is by definition a potential carcinogen in thyroid tissue (Abstract Here).

 

Induction of micronuclei, DNA strand breaks and HPRT mutations in cultured Chinese hamster V79 cells by the phytoestrogen coumoestrol.
Kulling SE, Metzler M. Food Chem Toxicol. 1997 Jun;35(6):605-13.

Coumoestrol (COUM), genistein (GEN) and daidzein (DAI) are major phytoestrogens present in numerous plants eaten by humans and food-producing animals.

The effects of COUM, GEN and DAI were studied in cultured Chinese hamster V79 cells at various endpoints. None of the substances affected the cytoplasmic microtubule complex or the mitotic spindle. However, COUM and GEN but not DAI proved to be strong inducers of DNA strand breaks and micronuclei containing acentric fragments, as shown with antikinetochore antibodies.

Full Abstract Here

 

The soya isoflavone content of rat diet can increase anxiety and stress hormone release in the male rat.
Hartley DE, Edwards JE, Spiller CE, Alom N, Tucci S, Seth P, Forsling ML, File SE. Psychopharmacology (Berl) 2003 Mar 5;

Isoflavones form one of the main classes of phytoestrogens and have been found to exert both oestrogenic and anti-oestrogenic effects on the central nervous system. The effects have not been limited to reproductive behaviour, but include effects on learning and anxiety and actions on the hypothalamo-pituitary axis. It is therefore possible that the soya content of diet could have significant effects on brain and behaviour and be an important source of between-laboratory variability.

Compared with the rats fed the iso-free diet, the rats fed the iso-150 diet spent significantly less time in active social interaction and made a significantly lower percentage of entries onto the open arms of the plus-maze, indicating anxiogenic effects in both animal tests. The groups did not differ in their basal corticosterone concentrations, but the iso-150 group had significantly elevated stress-induced corticosterone concentrations. Stress-induced plasma vasopressin concentrations were also significantly elevated in the iso-150 diet group compared with the iso-free rats.

Major changes in behavioural measures of anxiety and in stress hormones can result from the soya isoflavone content of rat diet. These changes are as striking as those seen following drug administration

 

Full Abstract Here

Exposure to Genistein During Gestation and Lactation Demasculinizes the Reproductive System in Rats.
Wisniewski AB, Klein SL, Lakshmanan Y, Gearhart JP. J Urol 2003 Apr;169(4):1582-1586

Exposure to the phytoestrogen genistein (Indofine Chemical Co., Somerville, New Jersey) can disrupt normal male sexual differentiation.

Males exposed to genistein had smaller anogenital distance and testis size, and delayed preputial separation. Perinatal exposure to genistein also caused long-term dysfunction in reproductive behavior, in which adult males exposed to genistein were less likely to mount, intromit and ejaculate during mating tests. Males exposed to genistein also had lower testosterone concentrations in adulthood.

Perinatal genistein exposure results in transient and lasting alterations in masculinization of the reproductive system. These results extend our knowledge of the effects of early genistein exposure on male development and may have implications for human health in terms of potential relationships of endocrine disrupters and urogenital abnormalities thought to be increasing in incidence in boys and men.

Full Abstract Here

 

Infant feeding with soy formula milk: effects on the testis and on blood testosterone levels in marmoset monkeys during the period of neonatal testicular activity.

Sharpe RM, Martin B, Morris K, Greig I, McKinnell C, McNeilly AS, Walker M. Hum Reprod 2002 Jul;17(7):1692-703.

SMA-fed males had mean testosterone levels of 2.8-3.1 ng/ml, typical of the 'neonatal testosterone rise', whereas SFM-fed males exhibited consistently lower mean levels (1.2-2.6 ng/ml); paired comparison in SMA-and SFM-fed co-twins at day 35-45 revealed 53-70% lower levels in 11 of 13 co-twins fed with SFM (P = 0.004).

Further evidence for suppression of testosterone levels in SFM-fed males came from comparison of the frequency of low testosterone levels (<0.5 ng/ml). In historical controls aged 35-45 days, two out of 22 values were <0.5 ng/ml, a similar frequency as found in control SMA-fed males (one out of 15 values <0.5 ng/ml). In contrast, 12 out of 15 values for SFM-fed males were <0.5 ng/ml (P < 0.001).

Based on the average isoflavone content of the SFM brand used, intake of isoflavones was estimated at 1.6-3.5 mg/kg/day in the SFM-fed marmosets which is 40-87% of that reported in 4 month human infants fed on a 100% SFM diet. It is therefore considered likely that similar, or larger, effects to those shown here in marmosets may occur in human male infants fed with SFM. Whether the changes described result in longer-term effects is under investigation.

Full Abstract Here

 

The phytoestrogens coumoestrol and genistein induce structural chromosomal aberrations in cultured human peripheral blood lymphocytes.
Kulling SE, Rosenberg B, Jacobs E, Metzler M.  Arch Toxicol. 1999 Feb;73(1):50-4.

These results, together with previously published reports on the induction of micronuclei and DNA strand breaks in cultured Chinese hamster V79 cells by COUM and GEN, but not DAI, suggest that some but not all phytoestrogens have the potential for genetic toxicity.

Full Abstract Here

 

Evaluation of environmental, nutritional, and host factors in cats with hyperthyroidism.
Kass PH, Peterson ME, Levy J, James K, Becker DV, Cowgill LD., J Vet Intern Med 1999 Jul-Aug;13(4):323-9

Compared with cats that did not eat canned food, those that ate commercially prepared canned food had an approximate 2-fold increase in risk of disease.

Full Abstract Here

 

Identification of phytoestrogens in the urine of male dogs.
Juniewicz PE, Pallante Morell S, Moser A, Ewing LL., J Steroid Biochem 1988 Dec;31(6):987-94

We used thermospray-mass spectrometry and GC-MS to identify the phytoestrogens daidzein, equol, formononetin and genistein in HPLC purified fractions of urine obtained from male beagles. Using the same techniques we also confirmed the presence of daidzein and genistein in the commercial diet fed to these same dogs.

In conclusion, phytoestrogens are present in urine of male beagles. Moreover, the commercial diet fed to these dogs contains isoflavones which can be converted to equol by intestinal microflora.

Full Abstract Here

 

Identification and concentration of soy isoflavones in commercial cat foods.
Court MH, Freeman LM., Am J Vet Res 2002 Feb;63(2):181-5

Genistein and daidzein are common constituents of commercial cat foods. Predictors of isoflavone content included ingredient labeling, food type, and food cost. Soy isoflavones in some commercial cat foods were detected in amounts predicted to have a biological effect.

Full Abstract Here

 

Effects of the protein phosphorylation inhibitor genistein on maturation of pig oocytes in vitro.
Jung T, Fulka J Jr, Lee C, Moor RM., J Reprod Fertil 1993 Jul;98(2):529-35

It is concluded that genistein inhibited protein phosphorylation is a regulator of chromatin condensation, whereas both new protein synthesis and phosphorylation appear to be required for nuclear membrane disassembly.

Full Abstract Here

 

Cell-transforming activity and mutagenicity of 5 phytoestrogens in cultured mammalian cells.
Tsutsui T, Tamura Y, Yagi E, Someya H, Hori I, Metzler M, Barrett JC.Int J Cancer 2003 Jun 20;105(3):312-20

Morphological transformation in SHE cells was elicited by all phytoestrogens, except, prunetin. The transforming activities were ranked as follows: genistein > coumestrol > daidzein > biochanin A. Somatic mutations in SHE cells at the Na(+)/K(+) ATPase and hprt loci were induced only by genistein, coumestrol, or daidzein. Chromosome aberrations were induced by genistein or coumestrol, and aneuploidy in the near diploid range was occurred by genistein or biochanin A. Genistein, biochanin A or daidzein induced DNA adduct formation in SHE cells with the abilities: genistein > biochanin A > daidzein. Prunetin was negative for any of these genetic endpoints. Our results provide evidence that genistein, coumestrol, daidzein and biochanin A induce cell transformation in SHE cells and that the transforming activities of these phytoestrogens correspond to at least 2 of the mutagenic effects by each phytoestrogen, i.e., gene mutations, chromosome aberrations, aneuploidy or DNA adduct formation, suggesting the possible involvement of mutagenicity in the initiation of phytoestrogen-induced carcinogenesis.

Full Abstract Here

 

 

 




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