New book in Dutch

Eet vet word slank

Eet vet word slank gepubliceerd januari 2013

In dit boek lees je o.a.: * heel veel informatie ter bevordering van je gezondheid; * hoe je door de juiste vetten te eten en te drinken kan afvallen; * hoe de overheid en de voedingsindustrie ons, uit financieel belang, verkeerd voorlichten; * dat je van bewerkte vetten ziek kan worden.

Trick and Treat:
How 'healthy eating' is making us ill
Trick and Treat cover

"A great book that shatters so many of the nutritional fantasies and fads of the last twenty years. Read it and prolong your life."
Clarissa Dickson Wright

Natural Health & Weight Loss cover

"NH&WL may be the best non-technical book on diet ever written"
Joel Kauffman, PhD, Professor Emeritus, University of the Sciences, Philadelphia, PA

Soy Online Service

Soy Formulas Are Not Hypoallergenic

American Journal of Clinical Nutrition 1990: 51: 705-6.

Dear Sir

In the highly informative review, “Soy products and the human diet,” by Erdman and Fordyce (1), I was surprised at the authors’ conclusion that “….soy formulas contain a less allergenic protein” than cow-milk-based formula (CMF). Abundant literature on the antigenicity and allergenicity of soy protein (SP) in infant feeding fail to support the authors’ conclusion. The SPs used in infant formulas appear to be equally and in some cases, more antigenic than the heat-treated CMFs.

From an immunological and biochemical standpoint, there is not a prior reason to believe that SP possesses inherently hypoallergenic properties. May et al. (2) noted the brisk antibody response in infants fed soy formula, whereas Eastham et al. (3) concluded that SP is at least as antigenic as cow-milk protein (CMP) and should be used with caution. In animal models, investigators have been able to induce both anaphylaxis and antibody production in guinea pigs, calves, rabbits and mice.

Protein size and diversity are important predictors of allergic response. The large molecular weights and multiple protein subclasses of SP rival the 20-30 antigenic fractions of bovine milk. One author found up to 24 fractions of SP potentially capable of antibody elicitation (4). Burks et al. (5), using enzyme-linked immunoassays (ELISA) in infants with atopic dermatitis (soy sensitised), demonstrated allergen-specific lgl: antibodies to the 7S, IIS, and whey protein fractions of soy extract. Other potentially allergenic or antinutritional substances found with SP include lectins, soya saponins, trypsin inhibitors and hemagglutinins. In addition, the molecular weights of SP fractions range from 8,000 to 600,000 Da -certainly large enough to stimulate antibody production and larger than most, if not all, of the nutritional proteins found in cow milk (6).

Clinical investigations with human infants validate the significance of SP antigenicity. In the past 35 years, nine studies compared the efficacy of SP – vs CMP-based formulas in the prevention of atopic symptoms of food allergy (vomiting, colic, diarrhoea, eczema, rhinitis and asthma) in infants at high risk of atophy. Eight of these studies concluded that the incidence of atopic disease was not effected by the exclusive feeding of soy formula. In the most recent clinical study comparing CMF to soy-based formula, Miskelly et al. (7) concluded, “…no evidence has so far emerged to support that soya milk is better than cow’s milk in regards to the risk of allergic disease.”

Finally, the clinical literature is replete with numerous studies demonstrating the deleterious effects of SP on multiple-organ systems. SP ingestion or inhalation has been associated with asthma, diarrhoea, anaphylactic shock, gastrointestinal injury and the classical symptoms of atopy, i.e., eczema, rhinitis, vomiting, diarrhoea, otitis media, etc. Cow-milk and SP allergy may also occur simultaneously or as a consequence of soy feeding after gastronintestinal insult. Hill et al. (8) found that >50% of the infants with CMP intolerance were also reactive to soy formula and Lothe et al. (9) demonstrated that 35% of the CMP-allergic infants were also allergic to soy.

With its inherent antigenic properties, lack of efficacy in preventing, atopic disease and frequency of simultaneous allergy in CMP-sensitised infants, one must conclude that SP is not hypoallergenic compared with CMF (10). The American Academy of Paediatrics Committee on Nutrition (AAP/CON) recommends against the use of SP formulas in the dietary management of documented clinical allergic reactions to CMP or in the routine management of colic (11).

Although soy-formula use is common in infants with suspected allergies (~24% of the total formula market), its routine use as a hypoallergenic substitute for CMP formulas is not supported by basic science or clinical literature.

In Cancer Research, Helferich compared soy protein isolates containing varying levels of isoflavones. The researchers found that estrogen-dependent tumor growth increased as the isoflavone content increased in the soy-containing diet.

Stephen A Witherly

Carnation Company

Nutritional Products Division



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