Inverse association of soy product intake with serum androgen and
estrogen concentrations in Japanese men
Inverse association of soy product intake with serum androgen and
estrogen concentrations in Japanese men.
Nagata C, Inaba S, Kawakami N, Kakizoe T, Shimizu H
Nutr Cancer 2000; 36:1 14-8
Abstract
The cross-sectional relationships of soy product intake and serum
testosterone, estrone, estradiol, sex hormone-binding globulin, and
dihydrotestosterone were examined in 69 Japanese men. Soy product
intake was estimated from a semiquantitative food frequency
questionnaire.
Serum estradiol concentration was significantly inversely correlated
with soy product intake (r = -0.32, p = 0.009), and serum estrone
concentration was nonsignificantly inversely correlated with soy
product intake (r = -0.24, p = 0.05) after controlling for age, body
mass index, smoking status, and ethanol intake.
Total and free testosterone concentrations were inversely correlated
with soy product intake after controlling for the covariates, but these
correlations were of border line significance (r = -0.25, p = 0.05 and
r = -0.25, p = 0.06, respectively).
Similar correlations were observed for these hormones with
isoflavone intake from soy products.
The data suggest that soy product intake may be associated with the
endogenous hormone levels in Japanese men.
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