New book in Dutch

Eet vet word slank

Eet vet word slank gepubliceerd januari 2013

In dit boek lees je o.a.: * heel veel informatie ter bevordering van je gezondheid; * hoe je door de juiste vetten te eten en te drinken kan afvallen; * hoe de overheid en de voedingsindustrie ons, uit financieel belang, verkeerd voorlichten; * dat je van bewerkte vetten ziek kan worden.

Trick and Treat:
How 'healthy eating' is making us ill
Trick and Treat cover

"A great book that shatters so many of the nutritional fantasies and fads of the last twenty years. Read it and prolong your life."
Clarissa Dickson Wright

Natural Health & Weight Loss cover

"NH&WL may be the best non-technical book on diet ever written"
Joel Kauffman, PhD, Professor Emeritus, University of the Sciences, Philadelphia, PA

Soy Online Service

Tofu and cognitive impairment — studies

Association of mid-life consumption of tofu with late life cognitive impairment and dementia: the Honolulu-Asia Aging Study.

White L, Petrovich H, Ross GW, Masaki K.

Fifth International Conference on Alzheimer's Disease, #487, 27 July 1996, Osaka, Japan.


Tofu and other soybean foods contain isoflavones - three ringed molecules bearing structural resemblance to steroidal hormones and having significant estrogen agonistic or antagonistic activities apparently related to their interactions with estrogen receptors and/or with enzymes involved in estrogen metabolism.

There is evidence suggesting that estrogens modulate neural and synaptic plasticity during aging. Male neurons have both estrogen and androgen receptors. Further, an enzyme (aromatase) that converts androgens to estrogens has been demonstrated in the medial forebrain, limbic system, hippocampus, and hypothalamus.

It was hypothesized that men had consistently high dietary intakes of tofu during middle life would experience different patterns of cognitive decline and dementia in late life, compared with men reporting little or no tofu consumption.

The Honolulu-Asia Aging Study is a longitudinal study of aging and dementia conducted in Japanese-American men who are members of the Honolulu Heart Program cohort. Mid-life patterns of consumption of tofu and several other foods were defined on the basis of food frequency interviews conducted in 1965 and 1972. The Cognitive Abilities Screening Instrument was administered to more than three thousand surviving participants aged 71-93 years during the 1991-93 examination cycle. DSM-HI-R, NINCDS-ADRDA, and California criteria were use for the diagnosis of dementia (all cause), AD and VsD.

We found an association of consistently high levels of tofu consumption in mid-life with low cognitive test scores (p=0.02) and (independently) with Alzheimer's disease in late life, controlling for all other relevant variables. The odds ratio for AD in persons who reported eating tofu at least twice weekly was 2.4 (95% CI 1.14-5.09), compared with persons reporting tofu consumption rarely or never.

Life-style risk factors for cognitive impairment.

White LR, Foley DJ, Havlik RJ

In: Strategies to prevent cognitive decline in late life, Fillit H, Butler RN, editors. London: Greenwich Medical Media; 1997. p. 23-32.


The EDB Program of NIA is involved in an epidemiological study of about 3,500 older Japanese-American men in Honolulu, Hawaii. As has been mentioned, prevalence rates of Alzheimer‚€™s disease are higher than in Japan. This study offers some unique features, which should be highlighted. This population has been under observation for about 25 years; so, data were collected many years earlier, before any effect of dementia could distort the data. Data were primarily on cardiovascular risk factors including dietary intake and indicators of cultural differences (more or less traditional Japanese). Preliminary results are available on a number of potential risk factors for Alzheimer‚€™s disease. There is no relationship with alcohol consumption, smoking, years of education, or low complexity occupations including working in sugar-cane or pineapple fields. What is unexpected, and somewhat inconsistent with the hypothesis of westernization being related to increased Alzheimer‚€™s disease, is the unexplained finding that components of the traditional Japanese diet, which include a high intake of green tea, tofu, and miso soup, are positively associated with Alzheimer‚€™s disease. This finding is being pursued in further analyses. Also, an unusual aspect of the study is a high autopsy rate among participants. The situation will allow study of structure-function relationships, including correlation of ante-mortem factors with Alzheimer‚€™s disease-specific findings of plaques and tangles and brain size. It is quite possible that certain factors will be related to structural changes and others to the clinical manifestations of Alzheimer‚€™s disease. It should be possible to evaluate these complex interrelationships within this rather unique population.

Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors.

O'Dell TJ, Kandel ER, Grant SG

Nature 1991 Oct 10 353:6344 558-60


Long-term potentiation (LTP) in the hippocampus is thought to contribute to memory formation. In the Ca1 region, LTP requires the NMDA (N-methyl-D-aspartate) receptor-dependent influx of Ca2+ and activation of serine and threonine protein kinases. Because of the high amount of protein tyrosine kinases in hippocampus and cerebellum, two regions implicated in learning and memory, we examined the possible additional requirement of tyrosine kinase activity in LTP. We first examined the specificity in brain of five inhibitors of tyrosine kinase and found that two of them, lavendustin A and genistein, showed substantially greater specificity for tyrosine kinase from hippocampus than for three serine-threonine kinases: protein kinase A, protein kinase C, and Ca2+/calmodulin kinase II. Lavendustin A and genistein selectively blocked the induction of LTP when applied in the bath or injected into the postsynaptic cell. By contrast, the inhibitors had no effect on the established LTP, on normal synaptic transmission, or on the neurotransmitter actions attributable to the actions of protein kinase A or protein kinase C. These data suggest that tyrosine kinase activity could be required postsynaptically for long-term synaptic plasticity in the hippocampus. As Ca2+ calmodulin kinase II or protein kinase C seem also to be required, the tyrosine kinases could participate postsynaptically in a kinase network together with serine and threonine kinases.



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