New book in Dutch

Eet vet word slank

Eet vet word slank gepubliceerd januari 2013

In dit boek lees je o.a.: * heel veel informatie ter bevordering van je gezondheid; * hoe je door de juiste vetten te eten en te drinken kan afvallen; * hoe de overheid en de voedingsindustrie ons, uit financieel belang, verkeerd voorlichten; * dat je van bewerkte vetten ziek kan worden.

Trick and Treat:
How 'healthy eating' is making us ill
Trick and Treat cover

"A great book that shatters so many of the nutritional fantasies and fads of the last twenty years. Read it and prolong your life."
Clarissa Dickson Wright

Natural Health & Weight Loss cover

"NH&WL may be the best non-technical book on diet ever written"
Joel Kauffman, PhD, Professor Emeritus, University of the Sciences, Philadelphia, PA

Soy Online Service

Effects of soy on rats, mice, birds and cattle

Rats & Mice:

Letter: The chance discovery of oestrogenic activity in laboratory rat cake.

Drane H, Patterson DS, Roberts BA, Saba N

Food Cosmet Toxicol 1975 Aug 13:4 491-2

Oestrogenic activity of soya-bean products.

Drane HM, Patterson DS, Roberts BA, Saba N

Food Cosmet Toxicol 1980 Aug 18:4 425-7

Dietary genistein exerts estrogenic effects upon the uterus, mammary gland and the hypothalamic/pituitary axis in rats.

Santell RC, Chang YC, Nair MG, Helferich WG

J Nutr 1997 Feb 127:2 263-9


These studies were undertaken to assess the estrogenic and antiestrogenic effects of dietary genistein.

To determine estrogenic effects, genistein was mixed into a modified AIN-76 or AIN-93G semipurified diet at 0 (negative control), 150, 375 or 750 microg/g and 17, beta-estradiol at 1.0 microg/g and fed to ovariectomized 70-d-old Sprague-Dawley rats.

Estrogenic potency was determined by analyzing uterine weight, mammary gland development, plasma prolactin and expression of uterine c-fos.

Dietary genistein (375 and 750 microg/g) increased uterine wet and dry weights (P < 0.05). Mammary gland regression following ovariectomy was significantly inhibited by dietary genistein at 750 microg/g (P < 0.05). Plasma prolactin was significantly greater in ovariectomized rats fed genistein (750 microg/g) compared with comparable rats not receiving genistein. The relative binding affinity of genistein to the estrogen receptor (ER) was 0.01 that of estradiol. Genistein (750 microg/g) induced the uterine expression of c-fos.

To evaluate potential antiestrogenic effects, genistein and estradiol were mixed into the modified AIN diets at the doses noted above and fed to ovariectomized rats.

Dietary genistein (375 or 750 microg/g) did not inhibit the effects of estradiol on uterine weight, mammary gland development or plasma prolactin. Serum concentration of total genistein (conjugated plus free) in rats fed 750 microg/g was 2.2 micromol/L and free genistein was 0.4 micromol/L.

Administration of dietary genistein at 750 microg/g can exert estrogenic effects in the uterus, mammary gland and hypothalamic/pituitary axis. Dietary genistein (750 microg/g) did not antagonize the action of estradiol in estradiol supplemented ovariectomized rats or in intact rats.


Phytoestrogens: adverse effects on reproduction in California quail

Leopold AS, Erwin M, Oh J, Browning B

Science 1976 Jan 9 191:4222 98-100


Phytoestrogens, largely formononetin and genistein, are produced in the leaves of stunted desert annuals in a dry year. When ingested by California quail, these compounds apparently inhibit reproduction and prevent the production of young that will not have adequate food. In a wet year, forbs grow vigorously and phytoestrogenic substances are largely absent. Quail then breed prolifically and the abundant seed crop carries the enlarged population through the winter.

Effects of dietary and parenteral estrogens on bobwhite reproduction.

Lien RJ, Cain JR, Beasom SL

Poult Sci 1987 Jan 66:1 154-61


Bobwhites were fed one of several doses (.01 to 1,000 micrograms/day) of estriol (E3), beta-estradiol-3-benzoate (E2B), diethylstilbestrol (DES), or biochanin-A (BA) during two 10-week trials.

The initial 2 weeks of each trial were short day length (10L:14D) followed by 8 weeks of long day length (16L:8D). In addition, female bobwhites were given daily injections containing dosages (.01 to 10 micrograms/day) of E2B, E3, and DES while housed on the same light regimen.

Reproductive performance as assessed by onset of lay, egg production, and egg fertility was depressed in a dose-dependent manner and was inhibited by dietary dosages of 1,000 micrograms/day of E3, DES, and E2B.

No consistent effects on reproductive performance were observed in bobwhites fed up to 1,000 micrograms/day of the phytoestrogen BA.

Injected estrogens appeared approximately 100 times more potent than dietary estrogens.

It was concluded that both dietary and parenteral estrogen can inhibit reproduction, but in order for phytoestrogen (BA) in natural feedstuffs to impair reproduction in bobwhites it would have to be consumed in excess of 1 mg/day.


Investigations in central Hessia on the occurrence of estrogenic activity content of cattle feed]

Khodabandehlou H, Hoffmann B, Pallauf J

DTW Dtsch Tierarztl Wochenschr 1997 Aug 104:8 291-4


In 21 farms which requested consultation for reasons of infertility problems feed samples (grass silage, n = 20; cornsilage, n = 19; hay, n = 9; cereal mixture, n = 3, brewers grains, n = 5, ensiled sugar beet tops, n = 1) were drawn for assay of free (aglycon) and glycosidic (glycosid) bound oestrogen activity.

Following sample preparation and extraction, the oestrogenic activity was determined using a radioreceptorassay and only those samples leading to a 50% displacement of the 3H-estradiol-17 beta-tracer were classified as oestrogen-positive; values were expressed as ng 17 beta-estradiol equivalents per g dry matter.

Selected samples clearly oestrogen-positive in the aglycone fraction were submitted to separation by HPLC and cytograms were established with the intention to allow an assignment of the oestrogenic activity to the following reference compounds, coumestrol, genistein, daidzein, formononetin, biochanin A, zeeralenon.

With regard to free oestrogenic activity (aglycon) most of the grass silages were positive while-with one exception - the cornsilages were negative as were the hay-samples. The brewers grain samples were likewise positive and negative. Distinctly lower concentrations were found for the glycosidic bound oestrogenic activity with highest levels determined in hay.

Results obtained after application of HPLC showed that the oestrogenic activity could particularly be attributed to daidzein and biochanin A. In the only oestrogen-positive cornsilage-sample the activity found corresponded with zearalenon.

Types and concentrations of the oestrogenic activity allow the conclusion that negative effects on reproduction cannot be excluded.



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