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A New Hypothesis on Spontaneous Remission of Cancer
Part 3: Clinical and epidemiological studies
The next course of action will involve scientific studies to validate my theory regarding spontaneous remission. This will involve large scale and comprehensive clinical and epidemiological studies.
Epidemiological studies will focus on the metabolic factors and their relationship with spontaneous remission. These retrospective studies will investigate the positive relationship between spontaneous remission of cancer on hand and the presence of both fever and starvation on the other hand. To avoid any controversies the remission cases to be studied should only be of microscopically confirmed cancer. The metabolic factors to be studied will be the presence of fever at least on one occasion as well as starvation prior to or during the febrile reaction. With regard to these metabolic factors both objective and subjective reporting should be accepted as valid. Clinical indicators of starvation include:
- Severe anorexia, especially in bed-ridden patients or those with high tumor loads.
- Recurrent bouts of vomiting e.g. tumors causing gastric or intestinal obstruction.
- The inability to ingest food e.g. in tumors of the palate, pharynx or esophagus.
- Severely debilitated or comatose patients.
- History of rapid weight loss.
- Major depression e.g. pancreatic tumors.
A similar retrospective, study of patients who responded to Coley's toxins needs to be carried out. The main aim of such a study will be to prove that the patients who responded to the treatment did so as a result of the fever induced in patients who were deprived of adequate nutrition. It will also show that those who had only one of these metabolic factors i.e. starvation or fever, did not respond as well as those with both fever and starvation occurring concurrently.
Clinical studies should also be carried out concurrently due to the fact that many cancer patients have already run out of options. Many of these patients who are currently receiving only palliative treatment will make good candidates for the clinical trials. The first step will involve a period of starvation ranging from 7 to 10 days. This period will allow for adequate mobilization of fatty acids and formation of ketone bodies. By the end of this period most non-neural tissues including cancer cells will be utilizing fatty acids and ketone bodies as their major sources of energy. Alternatively a ketogenic diet can be given to those patients who are unable to tolerate starvation or in those who are already undernourished. It may also be interesting to note at this point that some people have advocated for the use of insulin coma therapy as a treatment for cancer. I believe that the few cases of cancer remission that have been recorded as result of insulin therapy have occurred as a result of starvation combined with low-grade fevers. Insulin only augments the natural effect of starvation of lowering the blood sugar.
The second step in the clinical studies will involve suddenly increasing the metabolic rate of the malignant cells. Since most cancers are systemic diseases this will involve increasing the metabolic rate of the whole body. The three basic methods of causing a rapid and sustained increase in the metabolic rate include:
- Intravenous infusion of a mixed bacterial vaccine.
- Whole body hyperthermia using external devices.
- Intravenous thyroid hormone. [Tri-iodothyronine]
The first choice will involve the intravenous administration of a relatively high dose of a standardized mixed bacterial vaccine like Coley's toxins. The sole purpose of this infusion will be to stimulate the immune system cells to produce fever-inducing cytokines to enable the formation of an acute febrile response. High fevers lasting at least ten hours will probably be sufficient to achieve a measurable clinical response. Body temperature, blood pressure, and pulse rate should be closely monitored to enable clinicians to act rapidly in case of adverse reactions. The blood levels of glucose, fatty acids and ketones should also be measured to assess their overall and individual contribution to the efficacy of the treatment. Patients should be given appropriate information regarding the expected side effects. They should be informed that they will have to tolerate the side effects of fever since the analgesics commonly used to treat the generalized body pains tend to lower the fever which required for its direct therapeutic effect on cancer cells. Immediately after the treatment the patients should be assessed to determine the efficacy of the treatment. The final clinical protocol that will be formulated will make room for adjustments to cater for individual treatment. The patient's age, weight, sex, general health, tumor type, tumor size, tumor site and state of the immune system will have to be taken into account.
The second method of increasing the metabolic rate of previously starved cancer patients will involve the use of external heating devices. Since the devices and machines necessary for artificially increasing body temperature are already available in many leading research centers, this method can be quickly evaluated. This method of treatment will be particularly useful in cancers limited to specific organs or limbs.
The third method of increasing the metabolic rate will involve the use of thyroid hormones. The dose to be used should be as high as those used in the treatment of severe hypothyroidism. The only limitation will be the fact that some malignant cells may not respond to treatment because they may lack receptors for thyroid hormone.
Experiments to confirm the role of fever in boosting the immune response should also be carried out. I believe that some of the puzzling behavior observed in sick animals can now be understood. I believe that the reduced food appetite, lethargy and sleepiness observed in animals with acute infections, is a deliberate effort geared towards causing nutritional starvation. The main aim of this starvation is to reduce the glucose consumption of immune cell precursors and increase their use of fatty acid metabolites. This effect is then combined with the hypercatabolic state induced by the fever to stimulate the maturation of the immune cell precursors. Therefore it appears as though fever and anorexia, were invented by evolutionary forces to act primarily on immature immune cells. This activity is probably not confined to immature immune cells, since spontaneous remission proves it also acts other immature cells including undifferentiated malignant cells.
Finally many alternative cancer therapies in use today may have been inspired by actual cases of spontaneous remission caused by the combination of starvation and fever. The doctors who observed them may have considered other more obvious factors leading them to formulate erroneous theories on spontaneous regression. This may include the following:
1. Dr. Josef Issels; whole-body comprehensive immunotherapy.
2. Dr. M. Gerson; combined dietary regime.
3. Dr. Sam Chachoua; induced remission therapy.
4. Dr. Subgis Koroljow; insulin hypoglycemic therapy.
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